Election Buzz: A Look At Brain Science As 5 States Vote On Legalizing Pot

Five states — including California — are voting this fall on whether marijuana should be legal for recreational use. That has sparked questions about what we know — and don’t know — about marijuana’s effect on the brain.

Research is scarce. The U.S. Drug Enforcement Agency classifies marijuana as a Schedule I drug. That classification puts up barriers to conducting research on it, including a cumbersome DEA approval application and a requirement that scientists procure very specific marijuana plants.

One long-term study in New Zealand compared the IQs of people at age 13 and then through adolescence and adulthood to age 38. Those who used pot heavily from adolescence onward showed an average 8 percent drop in IQ. People who never smoked, by contrast, showed slightly increased IQ.

Critics pounced on the study, which was published in 2012, because it didn’t adjust for many other things that affect IQ such as home life or family income. And there’s no proof the IQ differences are due to pot.

One of those critics, Nicholas Jackson, now a senior statistician at UCLA, wondered what would happen if he could rule out some of those elements by comparing twins.

“Individuals that share the same genes, grew up in the same household, where the difference between them was that one of the twins was using marijuana and one was not,” Jackson said.

Jackson and Joshua Isen, now an assistant professor of psychology at the University of South Alabama, Mobile, conducted a study comparing IQ tests of twins age 9 to 12, before either had smoked marijuana, and then seven to 10 years later, after one had started.

“If marijuana was causing IQ decline, what we would expect to see is that the twin who goes on and uses marijuana should have IQ deficits,” Jackson said. “We don’t find that.”

IQ scores for both twins varied slightly over time. And for twins who smoked marijuana, there was no significant difference in effect between daily and occasional use.

So was the New Zealand finding wrong? The authors did not comment for this story but have said that the twins study of teenagers does not address the effects of decades of heavy marijuana use.

Marijuana seems to affect a particular kind of intelligence, like short term retention of vocabulary words and other information that you might learn in school, said Mitch Earleywine, a professor of psychology at the University of Albany.

“They haven’t learned a whole lot of vocabulary words or they never learned the capital of Maine because they were high at school that day,” he said. “But when it comes to things that are more liquid intelligence, more fluid intelligence, they’re usually pretty good at those because it requires just intelligence in the moment, so to speak.”

It’s not clear how marijuana use may keep “Augusta” from being filed next to “capital of Maine” in the brain. Some studies that compare brain scans of teenagers who use marijuana to those who don’t show thinner, less dense connections between lobes. Nora Volkow, director of the National Institute on Drug Abuse, said brains with less connectivity don’t work as well as they should.

“You could expect that that will decrease your capacity to memorize things and to learn them which is necessary to you to actually further develop your cognitive abilities,” she said.

But Volkow said there’s little proof that marijuana causes poor brain connections. Studies so far have not compared brains before and after pot. Maybe kids who are already having trouble in school are more likely to try marijuana. Still, she is convinced that marijuana is bad for the brains of adults who began smoking in their youth.

People who regularly smoked marijuana as teens, “are achieving much less both in their education as well as their profession as well as their economic earnings,” Volkow said. “They also tend to be much more dissatisfied with life. Many studies have shown that.”

NIDA is one of several agencies behind a major study that will map the effects of marijuana and other substances on brain development. The Adolescent Brain and Cognitive Development Study (ABCD) will follow 10,000 9- to 10- year-olds through early adulthood, using neuroimaging to map changes in the brain.

But as of now, the research suggests if you don’t start young and don’t use marijuana often, there’s not much evidence of permanent harm to the brain. That’s led some experts in marijuana brain science to say it might be OK to make pot legal, with strong oversight. That includes Kevin Hill, an assistant professor of psychiatry at Harvard Medical School.

“I’m not sure how I would vote [on the ballot question] at this point. I want to see sensible marijuana policy that works, that gives people what they want while limiting risk,” said Hill, who wrote Marijuana: The Unbiased Truth about the World’s Most Popular Weed. (Besides in California, the issue is on the ballot in Arizona, Nevada, Maine and Hill’s home state of Massachusetts.)

Hill would like to see stronger regulation of marijuana if it becomes legal, with limits on advertising and of edible products that attract children, as well as a higher rate of taxation than the proposed 12 percent. If Massachusetts approves marijuana for recreational use, it would not be legal for anyone under age 21, when most, but not all, brain development occurs.

Supporters of the California initiative say it adds more regulation at the state level rather than letting local jurisdictions set the rules. In addition, the state already has a system in place for overseeing medical marijuana, which is legal.

Opponents argue, among other things, that despite the proposed ban in the measure on use by anyone under 21, it will increase availability and use among teens and children. Also, some say it will lead to an influx of commercial businesses that are less restrictive than current medical marijuana businesses, increasing consumption overall.

An analysis released earlier this year by the University of California, San Francisco argues that the potential harm of marijuana goes beyond the brain. Marijuana smoke can damage the human body as tobacco does, and the current proposal to legalize it in California it could create a public health threat that has not been adequately measured, according to the researchers.

Nevertheless, the UCSF analysis accepts the premise that marijuana should ultimately be legalized given “the social inequities and large public costs of the failed War on Drugs.”

This story was produced by Kaiser Health News, an editorially independent program of the Kaiser Family Foundation.

This story is part of a partnership that includes WBUR, NPR and Kaiser Health News.

Categories: Capitol Desk, Public Health

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